Pregnancy complications in G20210A mutation carriers associated with high prothrombin activity

Abstract Objective To study the association between high activity of Factor II (prothrombin) in blood plasma with G20210A mutation and development great obstetrical syndromes. Material methods A prospective clinical cohort was conducted on 290 pregnant women (average age 31.7 ± 4.7 years old). The main group made up 140 patients, while control comprised 150 wild G20210G type. aim to evaluate venous during stages pregnancy regard trophoblast invasion waves. As per results, analysis value gestational complications carried out. Results In group, median (Me) ranged from 108% (preconception period) 144% (pregnancy) [95% CI 130–150]. patients GA type, significantly higher related periods, ranging 149 181% 142–195], p < 0.0001. With 148.5 180.6%, pregnancies had no complications. Higher levels were associated early and/or severe preeclampsia (PE) fetal growth retardation (FGR). Conclusion data obtained regarding plasma, juxtaposed syndromes, allow assume that manifestation PE FGR is this coagulation factor’s level activity. Threshold mutation, allowing predict PE, 171.0% at preconception stage (AUC – 0.86; 0.0001) within 7–8 weeks gestation it 181.3% 0.84; 0.0001).